ea0056p735 | Endocrine tumours and neoplasia | ECE2018
Herrera-Martinez AD
, van Dungen ESR
, Dogan F
, van Koetsveld1 PM
, Castano JP
, Feelders RA
, Hofland LJ
In vitro 3D cell culture systems seem to appropriately reproduce the tumor cell microenvironment, including nutrients-oxygen conditions and cell-cell interactions. These models may better mimic in vivo tumor conditions and more accurately reproduce drug treatments effects. Since most in vitro studies in neuroendocrine tumors (NETs) are performed in 2D culture systems (monolayer), we aimed to compare the monolayer system with a 3D spheroid cell cultur...